Ingredients selected for their scientific evidence.

  • (magnesium, vitamin C, vitamin D3, vitamin K2, vitamins B1, B2, B3, B5, B6, B12, folic acid, zinc, selenium, manganese, chromium, molybdenum, iodine)

    Key Benefits:

    · Support energy metabolism and help reduce tiredness and fatigue (magnesium, vitamin C, B2, B3, B5, B6, B12).

    · Contribute to the normal functioning of the nervous system and to psychological and cognitive function (B vitamins, magnesium, zinc).

    · Support the immune system and protection against oxidative damage (vitamin C, vitamin D, zinc, selenium, manganese).

    · Help with the metabolism of macronutrients and the maintenance of normal blood glucose levels (chromium).

    · Contribute to the maintenance of healthy bones (vitamin D and vitamin K).

    Scientific Evidence:

    Magnesium (magnesium citrate)
    • Magnesium supplementation and blood pressure (umbrella meta-analysis) (2024)

    https://pubmed.ncbi.nlm.nih.gov/39280209/

    • Magnesium supplementation and blood pressure (meta-analysis) (2025)

    https://pubmed.ncbi.nlm.nih.gov/41000008/

    • Oral magnesium supplementation and blood pressure (meta-analysis, RCT) (2016)

    https://pubmed.ncbi.nlm.nih.gov/27402922/

    Vitamin C (L-ascorbic acid)
    • Hemilä H, et al. Vitamin C for preventing and treating the common cold (Cochrane systematic review) (2013)

    https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000980.pub4/full

    Zinc (zinc citrate)
    • Johnstone J, et al.Oral zinc for the common cold (systematic review & meta-analysis) (2012)

    https://www.cmaj.ca/content/184/10/e551

    Vitamin K2 (menaquinone)
    • Vitamin K supplementation and vascular calcification (systematic review & meta-analysis) (2023)

    https://pmc.ncbi.nlm.nih.gov/articles/PMC10218696/

    Vitamin D3 (cholecalciferol)
    • Martineau/Jolliffe et al. Vitamin D supplementation to prevent acute respiratory infections (IPD meta-analysis) (2021)

    https://pubmed.ncbi.nlm.nih.gov/33798465/

    • Wang CH, et al. Optimal methods of vitamin D supplementation to prevent
    acute respiratory infections (dose–response meta-analysis) (2024)

    https://pubmed.ncbi.nlm.nih.gov/39143549/

    Vitamin B3 (niacin/nicotinamide)
    • D’Andrea E, et al.Niacin therapy and cardiovascular outcomes (systematic review & meta-analysis) (2019)

    https://pubmed.ncbi.nlm.nih.gov/30977858/

    Vitamin B5 (pantothenic acid / calcium pantothenate)

    https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/

    Vitamin B6 (pyridoxine)
    • Vitamin B6 for premenstrual syndrome (systematic review & meta-analysis) (2019)

    https://pmc.ncbi.nlm.nih.gov/articles/PMC27878/

    Vitamin B12 (methylcobalamin)
    • Vitamin B12 supplementation and cognitive outcomes (systematic review & meta-analysis) (2021)

    https://pubmed.ncbi.nlm.nih.gov/33809274/

    Folate (5-MTHF / folate)
    • Folic acid/B-vitamins and stroke outcomes (systematic review & meta-analysis) (2013)

    https://pubmed.ncbi.nlm.nih.gov/24282609/

    • L-methylfolate as adjunctive therapy in depression (systematic review & meta-
    analysis) (2022)

    https://pubmed.ncbi.nlm.nih.gov/34794190/

    Selenium (selenomethionine)
    • Selenium for preventing cancer (Cochrane systematic review) (2018)

    https://pubmed.ncbi.nlm.nih.gov/29376219/

    • Selenium, cardiovascular disease, and all-cause mortality: systematic review
    & meta-analysis of RCTs (2020)

    https://pubmed.ncbi.nlm.nih.gov/33053149/

    • Selenium supplementation in coronary heart disease (meta-analysis) (2017)

    https://pubmed.ncbi.nlm.nih.gov/28965605/

    Manganese (manganese gluconate)

    https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/

    Molybdenum (sodium molybdate)

    https://ods.od.nih.gov/factsheets/Molybdenum-HealthProfessional/

    Chromium (chromium picolinate)
    • Suksomboon N, et al. Chromium supplementation in diabetes (systematic
    review & meta-analysis) (2014)

    https://pubmed.ncbi.nlm.nih.gov/24635480/

    • Asbaghi O, et al. Chromium supplementation and glycemic control in T2DM (meta-analysis) (2020)

    https://pubmed.ncbi.nlm.nih.gov/32730903/

    • Zhao F, et al. Chromium supplements and HbA1c (meta-analysis) (2022)

    https://pubmed.ncbi.nlm.nih.gov/33783683/

  • • Muroya K, et al. Beta-glucan supplementation and fatigue outcomes (systematic review & meta-analysis) (2025)
    https://pubmed.ncbi.nlm.nih.gov/39875626/
    • Zhong K, et al. Yeast beta-glucan supplementation and URTI incidence/duration (systematic review & meta-analysis) (2021)
    https://pubmed.ncbi.nlm.nih.gov/33900466/
    • Vlassopoulou M, et al. Fungal beta-glucans in humans (systematic review; clinical evidence from included trials) (2021)
    https://pubmed.ncbi.nlm.nih.gov/33876798/

  • Naghsh N, et al. Umbrella meta-analysis (ECA): curcumin and inflammatory biomarkers (2023)
    https://pubmed.ncbi.nlm.nih.gov/36700039/
    • Dehzad MJ, et al. Turmeric/curcumin and glycemic indices (ECA meta-analysis) (2023)
    https://pubmed.ncbi.nlm.nih.gov/37748368/
    • Yuan F, et al. Curcuminoids and glycemic control/insulin resistance (systematic review & meta-analysis) (2022)
    https://pubmed.ncbi.nlm.nih.gov/35143971/
    • Kavyani Z, et al. Curcumin and inflammation/oxidative stress/endothelial biomarkers (meta-analysis) (2024)
    https://pubmed.ncbi.nlm.nih.gov/38945354/
    • Hsiao AF, et al. Curcuminoids in knee osteoarthritis (systematic review & meta-analysis) (2021)
    https://pubmed.ncbi.nlm.nih.gov/34537344/

  • • Han S, et al. Dietary polyamine intake and all-cause mortality / incident CVD (systematic review & dose-response meta-analysis of cohorts) (2024)
    https://pubmed.ncbi.nlm.nih.gov/39770955/
    • Liaqat H, et al. Wheat germ consumption and lipid/cardiometabolic markers (systematic review & meta-analysis) (2020)
    https://pubmed.ncbi.nlm.nih.gov/32523783/
    • Wirth R, et al. Spermidine supplementation in older adults (randomized controlled trial) (2022)
    https://pubmed.ncbi.nlm.nih.gov/35616942/
    Note: the clinical evidence of "spermidine supplementation" is still less abundant than the observational evidence on dietary intake of polyamines.

  • • Menon A, et al. Benefits, side effects, and uses of Hericium erinaceus as a supplement in humans (systematic review) (2025)
    https://pubmed.ncbi.nlm.nih.gov/40959699/
    • Mori K, et al. Hericium erinaceus and mild cognitive impairment (double-blind placebo-controlled trial) (2009)
    https://pubmed.ncbi.nlm.nih.gov/18844328/
    • Nagano M, et al. Hericium erinaceus: depression/anxiety/sleep in women (double-blind trial) (2010)
    https://pubmed.ncbi.nlm.nih.gov/20834180/
    • Vigna L, et al. Hericium erinaceus and mood/sleep symptoms (clinical study; not always described as a classic RCT) (2019)
    https://pubmed.ncbi.nlm.nih.gov/31118969/
    • Saitsu Y, et al. Oral intake of Hericium erinaceus and cognitive functions (RCT) (2019)
    https://pubmed.ncbi.nlm.nih.gov/31413233/

  • • Rosenfeldt F, et al. Coenzyme Q10 in the treatment of hypertension (systematic review & meta-analysis) (2007)
    https://pubmed.ncbi.nlm.nih.gov/17287847/
    • Jafari M, et al. Coenzyme Q10 supplementation and heart failure outcomes (systematic review) (2018)
    https://pubmed.ncbi.nlm.nih.gov/30122240/
    • Coenzyme Q10 and statin-associated muscle symptoms (systematic review & meta-analysis) (2025)
    https://pubmed.ncbi.nlm.nih.gov/41158831/
    • Coenzyme Q10 and heart failure clinical outcomes (systematic review & meta-analysis) (2017)
    https://pubmed.ncbi.nlm.nih.gov/28738783/

  • • Karimi M, et al. Curcumin + piperine co-supplementation and glycemic indices (meta-analysis) (2025)
    https://pubmed.ncbi.nlm.nih.gov/41393198/
    • Hosseini H, et al. Piperine + curcumin and lipid profile in metabolic syndrome (systematic review & meta-analysis) (2023)
    https://pubmed.ncbi.nlm.nih.gov/36649934/
    Note: robust meta-analyses of "piperine alone" with hard clinical outcomes are relatively scarce; the strongest evidence is usually in co-supplementation with curcumin.

  • Rao M, et al. Effect of Inulin-Type Carbohydrates on Insulin Resistance in T2DM and Obesity: Systematic Review and Meta-analysis (2019)
    https://pubmed.ncbi.nlm.nih.gov/31534973/
    • Fu L, et al. Associations between dietary fiber supplementation and cardiovascular risk factors: umbrella meta-analysis (2022)
    https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.972399/full
    • van der Schoot A, et al. The Effect of Fiber Supplementation on Chronic Constipation: Systematic Review and Meta-analysis (2022)
    https://pubmed.ncbi.nlm.nih.gov/35816465/

  • Serban MC, et al. Spirulina and lipid profile (systematic review & meta-analysis of RCT) (2016)
    https://pubmed.ncbi.nlm.nih.gov/26433766/
    • Rahnama I, et al. Spirulina supplementation and lipid profile (meta-analysis) (2023)
    https://pubmed.ncbi.nlm.nih.gov/37263369/
    • Hatami E, et al. Spirulina in type 2 diabetes: glycemia + lipids (systematic review & meta-analysis) (2021)
    https://pubmed.ncbi.nlm.nih.gov/34178867/
    • Zarezadeh M, et al. Spirulina and anthropometric indices (meta-analysis of RCT) (2021)
    https://pubmed.ncbi.nlm.nih.gov/32967062/
    • Mousavi S, et al. Spirulina and inflammation/oxidative stress biomarkers (meta-analysis of RCT) (2025)
    https://www.sciencedirect.com/science/article/pii/S1756464625002877

  • Houshialsadat Z, et al. Broccoli sprout supplementation and cardiometabolic health (systematic review & meta-analysis) (2023)
    https://brieflands.com/journals/jjnpp/articles/129402
    • McGuinness G, et al. Sulforaphane treatment for ASD (systematic review) (2020)
    https://pubmed.ncbi.nlm.nih.gov/33013262/
    • Wang R, et al. Sulforaphane in autism spectrum disorder (systematic review & meta-analysis) (2025)
    https://www.excli.de/excli/article/view/8239/5273
    • Kassar O, et al. Sulforaphane in schizophrenia (systematic review & meta-analysis of RCT) (2025)
    https://pubmed.ncbi.nlm.nih.gov/41184790/
    • Baladia E, et al. Broccoli consumption and cancer risk (systematic review & meta-analysis of observational studies) (2024)
    https://www.mdpi.com/2072-6643/16/11/1583

  • Wang X, et al. Rhodiola rosea supplementation on endurance performance and biomarkers (systematic review & meta-analysis) (2025)
    https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1645346/full
    • Ishaque S, et al. Rhodiola rosea for physical and mental fatigue (systematic review) (2012)
    https://pubmed.ncbi.nlm.nih.gov/22643043/
    • Tóth-Mészáros A, et al. Adaptogenic plants on stress (systematic review & meta-analysis; includes adaptogens according to study criteria) (2023)
    https://www.sciencedirect.com/science/article/pii/S1756464623002955
    • Rhodiola rosea supplementation on sports performance (systematic review) (2023)
    https://pubmed.ncbi.nlm.nih.gov/37495266/

  • • Jafari A, et al. Ganoderma lucidum supplementation and cardiometabolic markers (systematic review & meta-analysis of RCT) (2025)

    https://pubmed.ncbi.nlm.nih.gov/40510787/

    • Jin X, et al. Ganoderma lucidum for cancer treatment (Cochrane systematic review) (2016)

    https://pubmed.ncbi.nlm.nih.gov/27045603/

    • Klupp NL, et al. Ganoderma lucidum for cardiovascular risk factors (Cochrane systematic review) (2015)

    https://pubmed.ncbi.nlm.nih.gov/25686270/

    • Zhong L, et al. Medicinal mushroom extracts as adjuvant therapy in cancer (meta-analysis; includes Ganoderma lucidum according to the study) (2019)

    https://pubmed.ncbi.nlm.nih.gov/31333449/

  • Faghfouri AH, et al. NAC on inflammation and oxidative stress biomarkers (systematic review & meta-analysis) (2020)
    https://pubmed.ncbi.nlm.nih.gov/32726657/
    • Fowdar K, et al. NAC and COPD exacerbations (meta-analysis of RCTs) (2017)
    https://pubmed.ncbi.nlm.nih.gov/28109565/
    • Zheng W, et al. Adjunctive NAC in major mental disorders (systematic review & meta-analysis) (2018)
    https://pubmed.ncbi.nlm.nih.gov/29457216/
    • Kishi T, et al. NAC as adjunctive treatment for bipolar depression/MDD (systematic review & meta-analysis) (2020)
    https://pubmed.ncbi.nlm.nih.gov/32767039/
    • N-acetylcysteine treatment in chronic obstructive pulmonary disease (systematic review/meta-analysis) (2024)
    https://www.archbronconeumol.org/en-n-acetylcysteine-treatment-in-chronic-obstructive-articulo-S0300289624000693

  • General note: in probiotics, the "strongest" evidence is usually by specific strain, dosage, and population. Meta-analyses often group multiple strains; if you want, I can refine it to evidence by specific commercial strain.

    Bifidobacterium bifidum
    • Probiotics for IBS: systematic review & network meta-analysis (includes comparisons by species/blends) (2022)
    https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.859967/full
    • Probiotic supplementation and respiratory infection outcomes (systematic review & meta-analysis) (2021)
    https://pubmed.ncbi.nlm.nih.gov/33481001/
    • Orally ingested probiotics and respiratory tract infections (systematic review & meta-analysis) (2022)
    https://pubmed.ncbi.nlm.nih.gov/35948276/
    • Specific RCT (example of strain): Guglielmetti S, et al. Bifidobacterium bifidum MIMBb75 alleviates IBS (2011)
    https://pubmed.ncbi.nlm.nih.gov/21418261/

    Lactobacillus acidophilus
    • Probiotics and blood lipid concentrations (meta-analysis of RCTs; includes L.acidophilus among studied strains) (2015)
    https://pubmed.ncbi.nlm.nih.gov/26512560/
    • Probiotics and total cholesterol/LDL (meta-analysis of RCTs; includes strains with L. acidophilus) (2018)
    https://journals.lww.com/md-journal/fulltext/2018/02020/the_effects_of_probiotics_on_total_cholesterol__a.8.
    aspx
    • Probiotics and respiratory tract infections (systematic review & meta-analysis) (2022)
    https://pubmed.ncbi.nlm.nih.gov/35948276/

    Lactobacillus plantarum
    • L. plantarum supplementation and lipid profile (systematic review & meta-analysis) (2025)
    https://www.mdpi.com/2304-8158/14/19/3300
    • Probiotics for IBS: systematic review & network meta-analysis (2022)
    https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.859967/full
    • Probiotics and respiratory tract infections (systematic review & meta-analysis) (2022)
    https://pubmed.ncbi.nlm.nih.gov/35948276/

fuelti-ingredientes.jpg

Transparent doses, rigorous selection.

A daily formula in sachets that combines bioactive vitamins and minerals with prebiotic fiber, probiotics, and standardized botanical compounds.
We believe you shouldn't settle for low-quality raw materials. We select each ingredient for its bioactive form, purity, and traceability.

What Fuelti F1 can contribute**

Energy and fatigue

Vitamins B1, B2, B3, B5, B6, B12, C, magnesium, and manganese contribute to normal energy metabolism; B2, B3, B5, B6, B12, C, and magnesium contribute to the reduction of tiredness and fatigue.

Immune system

Vitamins C, D, B6, B12, folate, zinc, and selenium contribute to the normal functioning of the immune system.

Cognitive and nervous function

Zinc contributes to normal cognitive function; B1, B3, B6, B12, C, and magnesium contribute to psychological function and the normal functioning of the nervous system.

Muscles and bones

Vitamin D and magnesium contribute to normal muscle function; D, K, magnesium, and manganese contribute to the maintenance of normal bones; K contributes to coagulation.

Antioxidant protection

Vitamin C, zinc, selenium, and manganese contribute to the protection of cells against oxidative damage.

Metabolism and glucose

Zinc contributes to the normal metabolism of macronutrients; chromium contributes to the maintenance of normal blood glucose levels.

Skin, hair, and nails

Vitamin C contributes to the normal formation of collagen for the normal function of the skin; zinc contributes to the maintenance of normal skin, hair, and nails; selenium contributes to the maintenance of normal hair and nails.

Thyroid and tissues

Selenium contributes to normal thyroid function; manganese contributes to the normal formation of connective tissue.

View technical sheet

** Authorized health property statements when significant amounts are reached per daily dose. Check the labeling for %DV and usage instructions.